Depression Articles

Depression and Diabetes

Depression not only affects your brain and behavior— it affects your entire body.

Depression has been linked with other health problems, including diabetes.

Dealing with more than one health problem at a time can be difficult, so proper treatment is important.


What is depression?

Major depressive disorder, or depression, is a serious mental illness. Depression interferes with your daily life and routine and reduces your quality of life. about 6.7 percent of u.s. adults ages 18 and older have depression. (1)

  • Signs and Symptoms of Depression
  • ongoing sad, anxious, or empty feelings
  • feeling hopeless
  • feeling guilty, worthless, or helpless
  • feeling irritable or restless
  • loss of interest in activities or hobbies once enjoyable,
  • including sex
  • feeling tired all the time
  • Difficulty concentrating, remembering details, or making
  • decisions
  • Difficulty falling asleep or staying asleep, a condition
  • called insomnia, or sleeping all the time
  • overeating or loss of appetite
  • thoughts of death and suicide or suicide attempts
  • ongoing aches and pains, headaches, cramps, or digestive
  • problems that do not ease with treatment.

What is diabetes?

Diabetes is an illness that affects the way the body uses digested food for energy. most of the food we eat is broken down into a type of sugar called glucose. Glucose is an important source of fuel for the body and the main source of fuel for the brain. the body also produces a hormone called insulin. insulin helps cells throughout the body absorb glucose and use it for energy. Diabetes reduces or destroys the body’s ability to make or use insulin properly. Without insulin, glucose builds up in the blood, and the body’s cells are starved of energy.

How are depression and diabetes linked?

Studies show that depression and diabetes may be linked, but scientists do not yet know whether depression increases the risk of diabetes or diabetes increases the risk of depression. but current research suggests that both cases are possible. in addition to possibly increasing your risk for depression, diabetes may make symptoms of depression worse. The stress of managing diabetes every day and the effects of diabetes on the brain may also contribute to depression. (2,3) 

in the United States, people with diabetes are twice as likely as the average person to have depression. (4) At the same time, some symptoms of depression may reduce overall physical and mental health, not only increasing your risk for diabetes but making diabetes symptoms worse. For example, overeating may cause weight gain, a major risk factor for diabetes. Fatigue or feelings of worthlessness may cause you to ignore a special diet or medication plan needed to control your diabetes, thus worsening your diabetes symptoms. Studies have shown that people with diabetes and depression have more severe diabetes symptoms than people who have diabetes alone. (4)


1. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry. 2005 Jun; 62(6): 617–27.

2. Golden SH, Lazo M, Carnethon M, Bertoni AG, Schreiner PJ, Roux AV, Lee HB, lyketsos C. Examining a bidirectional association between depressive symptoms and diabetes. JAMA. 2008 Jun 18; 299(23):2751–9.

3. KumarA, Gupta R, Thomas A, Ajilore O, Hellemann G. Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression. Arch Gen Psychiatry. 2009 Mar; 66(3):324–30.

4. Egede LE, Zheng D, Simpson K. Comorbid depression is associated with increased health care use and expenditures in individuals with diabetes. Diabetes Care. 2002 Mar; 25(3):464–70.

 Source: National Institute of Mental Health